A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kulkarni, Suresh V.
- Formulation and In Vitro Evaluation of Floating Matrix Tablets of Ofloxacin
Authors
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 1 (2011), Pagination: 17-22Abstract
The present study concerns the development of floating tablets of ofloxacin which were designed to prolong the gastric residence time after oral administration. Ofloxacin is a fluoroquinolone antibacterial agent which is highly effective against gram positive and gram negative bacteria. Ofloxacin floating tablets were prepared by wet granulation method incorporating natural polymer like guar gum, locust bean gum, either alone or in combination with HPMC K100M as swelling polymers, with sodium bicarbonate as gas generating agent and were evaluated for parameters such as Weight variation, Hardness, Friability, Drug content, Swelling index, in vitro buoyancy study, in vitro drug release study. All the formulation showed compliance with pharmacopieal standards. Based on the evaluation results, F3 and F6 formulations were selected as the best formulations and were checked for stability as per ICH guidelines. These results indicated that the selected formulations were stable. The drug release profile of the best formulations was well controlled and uniform throughout the dissolution studies. The drug release of optimized formulation follows the Higuchi kinetic model, and the mechanism is found to be non-Fickian/anomalous according to Korsmeyer-Peppas equation.Keywords
Floating Tablets, Ofloxacin, Guar Gum, Locust Bean Gum.
- Formulation and Evaluation of Nicorandil Chewing Gum
Authors
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
2 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 4 (2010), Pagination: 301-306Abstract
The study was to formulate and evaluate medicated chewing gum of Nicorandil, a novel potassium channel opener used in cardiovascular diseases. The chewing gums were prepared by direct compression method using different ratio of directly compressible gum base (pharmagum-M) in order to obtain new formulation. Eight different formulations of chewing gums of Nicorandil were prepared, which contains various concentration of pharmagum M. The chewing gums which are prepared by direct compression method were characterized by pre compression characters, post compression character, buccal absorption study, drug content, and in vitro drug release studies. All the formulations gave satisfactory results in terms of pre compression characters, post compression character, buccal absorption study, drug content, and in vitro drug release. The best compression characters and in vitro drug release profile were achieved in formulations F4, F5 and F6 with a gum concentration of 84%, 86% and 88% respectively.Keywords
Chewing gum, Buccal absorption, Nicorandil, Pharmagum M, Sorbitol.- Design and Evaluation of the Fast Dissolving Tablets of Aceclofenac by Sublimation Technique
Authors
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
2 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 233-236Abstract
The purpose of this study was to formulate and evaluate fast dissolving tablet of aceclofenac by sublimation technology using camphor. Sodium starch glycolate and crospovidone were used as superdisintegrants. Tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index. Tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro dispersion and in vitro dissolution. In vitro release studies were performed using USP XXII dissolution apparatus type II (Electro lab, Mumbai, India) paddle method in 900 ml of pH-7.4 at 75 rpm. Among all the formulation, F-6 shows 83.26% release at the end of 22 min. Thus, F-6 was considered as the best among the other formulations. The selected formulation F-6 was subjected to stability studies for three months, which showed stability with respect to release pattern.Keywords
Aceclofenac, Sodium Starch Glycolate, Crospovidone, Fast Dissolving Tablets.- Use of Hydrophilic Natural Guar Gum in Formulation of Controlled-Release Matrix Tablets of Metformin Hydrochloride and Its Comparison with Marketed Product
Authors
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, IN
2 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B. H. Road, Tumkur-572102, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 193-197Abstract
In the present investigation an attempt was made to formulate the oral controlled release metformin hydrochloride matrix tablets by using Guar gum as rate controlling polymer and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by wet granulation method. Granules were prepared and evaluated for loose bulk density, tapped density, compressibility index and angle of repose, shows satisfactory results. All the granules were lubricated and compressed using 12.8 mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, in vitro release studies and swelling index. All the formulations showed compliance with Pharmacopoeial standards. The in vitro dissolution study was carried out for 12 hours using paddle (USP type II) method in phosphate buffer (pH 6.8) as dissolution media. The prepared matrix tablets were shown 99.92%, 97.41%, 94.95%, 89.29%, 86.41% and 84.72% release over a period of 12 hours. Formulations F-1 and F-2 failed to sustain release beyond 9 hours and 11 hours, respectively. Among all the formulations, F-5 showed the controlled release of drug for 12 hours with 86.41% release and the release profile was close to the marketed sample of metformin hydrochloride (M-SR). Selected formulation (F-5) was subjected to stability studies for 3 months, which showed stability with respect to release pattern. The drug release follows first order kinetics and the mechanism was found to be diffusion coupled with erosion.
Keywords
Metformin Hydrochloride, Guar Gum, Matrix Tablets, Wet Granulation, Controlled Release.- Formulation and Evaluation of Controlled Release Microspheres of Zidovudine
Authors
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
2 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B. H. Road, Tumkur-572102, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 96-99Abstract
The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of zidovudine, using Copolymers Eudragit S 100 and RL 100 (acrylic and methacrylic acid esters) and Ethyl cellulose as the retardant material. Microspheres were prepared by solvent evaporation method using an acetone/liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties, drug loading, as well by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The in vitro release studies were performed in pH 7.4, phosphate buffer. The prepared microspheres were white, free flowing and spherical in shape. The drugloaded microspheres show 81-93% of entrapment and release was extended more than 10hrs. Stability studies revealed that polymers used were stable and compatible with the drug and there is no significant effect on physical characteristics, drug content and dissolution profile of the microspheres. Scanning electron microscopy study revealed that the microspheres were spherical with rough surface. The best-fit release kinetics was achieved with Higuchi's plot followed by First order and Zero order. The release of Zidovudine was influenced by the drug to polymer ratio, particle size&was found to be diffusion controlled.